The Benzo Bends

This article explores the potential problems with long-term use of anti-anxiety medication and the importance of re-humanising the treatment of emotional distress. The original article, published in the Irish Examiner can be read here

 

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By Liz Dunphy

Every morning Carmel wakes up from a fitful, toxic sleep in her Tipperary home. Her whole body vibrates like an internal jackhammer is belting her from inside — a loud sharp tinnitus floods her brain with distracting noise, her muscles forget how to function and her skin feels too tight for her body.

These are just some of the symptoms that have plagued Carmel for 19 long months since she stopped taking low daily doses of Valium which she was prescribed since August 2007.

Valium (or diazepam) is a benzodiazepine, a drug mostly used to treat anxiety disorders and muscle spasms. Benzodiazepines enhance the effect of the brain’s tranquilising neurotransmitter GABA which slows down over-activity to reduce symptoms of anxiety.

Many others could be experiencing Carmel’s painful and isolating withdrawal symptoms in Ireland today. The 2012 HSE PCRS report which lists the 100 medications most frequently prescribed to medical card patients ranked diazepam as the 26th most prescribed drug in Ireland, having dropped one place in Ireland’s drug popularity stakes from 25th place in 2011.

There is no official data on how frequently private prescriptions for benzodiazepines are issued, but Minister Kathleen Lynch says benzodiazepines are being excessively prescribed.

“We have to take a serious look at prescribing practices across the whole Department of Health, the problem is not just limited to psychiatric illnesses,” says Minister Lynch.

Ivor Browne is Professor Emeritus of Psychiatry at UCD, he was the Chief Psychiatrist of the Eastern Health Board and he is an eminent author on mental health.

Browne believes that benzodiazepines can be useful for relieving temporary anxiety but they should not be used on any regular or long-term basis because they are habit-forming.

“Anything that removes anxiety will be potentially addictive,” says Browne.

“Valium or its generic form Anxicalm can be effective, but all of these drugs are grossly overused, the person experiencing difficulties must work to overcome the traumas they have suffered with the support of a therapist.

“Psychotherapy, when it’s effectively undertaken, is the only real therapy. And Prozac and all other SSRIs (Selective Serotonin Reuptake Inhibitors, used as antidepressants) are actually dangerous and in my opinion should never be used,” says Browne.

“Everything is disconnected in our society when everything in reality is interconnected, this needs to change to solve our societal problems.

“We need to recognise that the heart is our real centre, not the brain. All our emotional life is centred in the heart and there are more messages going from the heart to the brain than vice-versa. There’s an awful lot yet to be understood,” says Browne.

Prof David Healy is the Professor of Psychopharmacology at Bangor University in Wales, he is Irish and his innovative website www.RxISK.org  invites people to research and report the benefits and side effects experienced when using prescription drugs. People can record their experiences on the website which will generate a free RxISK report that they can bring to their own doctor.

The gathered accounts form a database that aims to make medicine safer for patients. Healy believes it can also help to equalise power between doctors and patients by giving patients an option to record their symptoms with other medical professionals for free. And Healy believes that equalising that power is vital to improving our healthcare system.

“In the 1960s drugs were viewed as poisons. The magic of medicine was that doctors could use poison to produce good. Industry has changed this model, turning pharmaceuticals into something to be used as a fertiliser, to be sprinkled widely, but these drugs are generally tested on people for four to six weeks, not for the months or years that people are actually prescribed them for.

“The human body can take poisons for a month — but not for indefinite, constant periods of time without doing damage,” says Healy.

Bridget Hayes, a mother of three is from Limerick, she was prescribed Xanax for 20 years to treat anxiety which began when she experienced thyroid problems.

“I feel like I’ve lost 20 years of my life. I was turned into an addict. I went to hospital as a day patient for years and no one said that I shouldn’t be on all these medications for so long, no one ever mentioned that they could be addictive either,” says Hayes.

“And they never offered counselling, even though they had a psychotherapist in that hospital. They just dish out tablets, and there are obviously reasons why people feel anxious or depressed which they need to talk about and understand. Psychotherapy should be the first port of call for these problems.”

Echoing concerns voiced by Prof Healy and Prof Browne about the additional dangers of SSRIs, Hayes noted that when an SSRI called Seroxat was added to her drug cocktail things got even worse.

“On Seroxat I lost all emotion, I couldn’t feel anything and I didn’t care about anyone, least of all myself. I had never had depression before but this anti-depressant made me feel suicidal. I started drinking heavily and I tried to kill myself a few times.”

Hayes realised that the medication was making her worse, and asked to stop.

“Dr Terry Lynch saved me. I read his book Beyond Prozac and I recognised myself in it. I started the Ashton method with Dr Lynch to come off Xanax, he taught me coping strategies and he’s a huge support,” says Hayes.

The Ashton method is a protocol for benzodiazepine withdrawal developed by Professor Heather Ashton, an Emeritus Professor of Clinical Psycho-pharmacology at the University of Newcastle upon Tyne, England, in which you slowly reduce your dose while managing your symptoms. The Ashton Manual, which includes tapering schedules, is available on www.benzo.org.uk

“Once I came off Xanax and only took small doses of Valium I suddenly regained feelings and memories,” says Hayes. “My parents died a few years ago but I cried over their deaths for the first time recently, I had been so numbed by medication that I couldn’t feel any emotions.”

Hayes still has good and bad days but she has learned coping mechanisms, like deep breathing to deal with anxiety without medication.

“I feel cheated from so many years of my life. I have to go through hell to get off the medication and the people who put me on it can’t help me. The receptors in my brain are still damaged from the medication and it will take time to heal,” says Hayes.

“And it’s such a contradiction, these drugs are known to cause depression and anxiety as a side effect, yet people are prescribed them to treat those very symptoms.”

Dr Terry Lynch who helped Hayes with her benzodiazepine withdrawal, practiced as a GP before noticing problems in how medicine addressed mental health issues. He writes books on the topic (including a best seller Beyond Prozac, and a new book Depression Delusion, Vol.

One: The Myth of the Brain Chemical Imbalance, published this month). He now works full time helping people to improve their mental health through a combination of emotional, psychological and physical interventions, including medication.

“The existence of brain chemical imbalances, which psychiatric drugs are supposedly designed to correct, has never been scientifically verified. It’s a widely promoted and accepted myth. The pain and distress are very real but the chemical imbalance is not.

“These problems need to be addressed from a broader perspective, one that includes the emotional and psychological aspects of the person as well as the physical.

“The starting point should be seeking to make sense of people’s experiences and emotions at a human level,” says Lynch.

“Generally the medical profession now accept that benzodiazepines can be addictive and can cause difficult withdrawal symptoms but that awareness came belatedly.”

Lynch is concerned that a similarly delayed recognition of the potential problems with SSRIs may be currently unfolding. “As a society, we need to reconsider whether a biologically-dominated model for emotional and mental health and wellbeing is best for people or not,” he says.

Unexpected journeys can begin in the most mundane of ways. Mary*, a young mother from Tipperary fell off a slide while on holiday when holding her four-year-old on her lap.

“I got burning nerve pains after the fall, I thought that I had a degenerative neurological disease and I got quite depressed. My GP gave me an anti-depressant called sertraline (a SSRI), Xanax (alprazolam — a benzodiazepine) and the sleeping pill zopiclone ( a Z drug that works in a very similar way to benzodiazepines).

“Four weeks later I experienced severe, deep twitching in my legs and I still had burning nerve pains. I went to see a consultant who prescribed amitriptyline which worked well and ended my nerve pain, but afterwards I was hospitalised for tachycardia, which was actually quite lucky because the hospital diagnosed drug-induced arrhythmia, so I knew then that the medication was causing problems.”

Mary* only took the medication for six weeks but she has battled withdrawal symptoms for 13 months. “I asked to come off the medication and I didn’t crave it at all but my body and brain just couldn’t adapt quickly to functioning without them. But my cousin took them for three to four months and stopped taking them with no problems, so we all react differently,” says Mary*.

“I found that my symptoms matched the benzodiazepine withdrawal symptoms others reported on the internet. I learned that certain substances, like sugar and alcohol really aggravated my symptoms because they excite the nervous system, and MSG is a neurotoxin anyway so this worsens my symptoms too.

“Once I had information I felt more in control of what was happening. But Baylissa Frederick really saved me, she set up great online resources http://www.RecoveryRoad.org and a counselling website http://www.baylissa.co.uk. Without Baylissa’s help and support I’d either be on a very hard, painful, lonely road or else I’d be dead.”

Baylissa Frederick, the woman that Mary* attributes with helping her to cope with withdrawal, was first prescribed the benzodiazepine clonazepam in early 1998 for dystonia, a movement disorder.

“I didn’t know the drug was addictive until I started feeling unwell, I exhausted diagnostic tests and had multiple emergency visits to casualty, before I found the Ashton Manual online.”

“Of all the people I’ve supported, 90% found out the drug was the cause of their problems via the internet and asked their doctors to come off it. They print off tapering schedules from the Ashton Manual to bring to their doctors.

“For those on the drug who plan to stop taking it, never stop abruptly. Speak to your doctor and find a tapering schedule that is safe and not rushed.”

Frederick believes that normal emotions such as grief and stress are now pathologised.

Instead of allowing people to process these feelings and deal with them through talking and human support, people visit their GPs and end up with a prescription to a drug that could potentially cause them further problems.

“Many of the people I support were put on benzos, z-drugs and antidepressants for normal reactions to grief. At first I was shocked at how many had become dependent on these meds because of a bereavement,” says Frederick.

“Benzodiazepines basically put a chemical cushion between you and reality,” says Dr John Dunphy, a GP in Carrigaline, Co Cork, “that cushion can be very useful if you hit a rocky patch that is too uncomfortable to bear temporarily — but the problem is that that cushion can also smother you if it’s not closely monitored.”

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Healthy eating slows down mental decline

Good news for your brain and body today! A new study shows that healthy eating slows down cognitive decline.

An article about the study was published in this week’s Irish Medical Times, we’ve copied it below for you to read, and we’ve peppered the article with some videos showing quick, easy and healthy recipe demonstrations.

Happy eating!

 

A comprehensive programme providing older people at risk of dementia with healthy eating guidance, exercise, brain training, and management of metabolic and vascular risk factors appears to slow down cognitive decline, according to the first ever randomised controlled trial of its kind, published in The Lancet.


In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) study, researchers led by Prof Miia Kivipelto from the Karolinska Institutet in Stockholm, Sweden, National Institute for Health and Welfare in Helsinki, and University of Eastern Finland, assessed the effects on brain function of a comprehensive intervention aimed at addressing some of the most important risk factors for age-related dementia, such as high body-mass index and heart health.

A total of 1,260 people from across Finland, aged 60–77 years, were included in the study, with half randomly allocated to the intervention group, and half allocated to a control group, who received regular health advice only.

All of the study participants were deemed to be at risk of dementia, based on standardised test scores.

 

The intensive intervention consisted of regular meetings over two years with physicians, nurses, and other health professionals, with participants given comprehensive advice on maintaining a healthy diet, exercise programmes including both muscle and cardiovascular training, brain training exercises, and management of metabolic and vascular risk factors through regular blood tests, and other means.

After two years, study participants’ mental function was scored using a standard test, the Neuropsychological Test Battery (NTB), where a higher score corresponds to better mental functioning.

 

 

Overall test scores in the intervention group were 25 per cent higher than in the control group.

For some parts of the test, the difference between groups was even more striking — for executive functioning (the brain’s ability to organise and regulate thought processes) scores were 83 per cent higher in the intervention group, and processing speed was 150 per cent higher.

 

Based on a pre-specified analysis, the intervention appeared to have no effect on patients’ memory. However, based on post-hoc analyses, there was a difference in memory scores between the intervention and control groups.

According to Prof Kivipelto, much previous research has shown that there are links between cognitive decline in older people and factors such as diet, heart health, and fitness. “However, our study is the first large randomised controlled trial to show that an intensive programme aimed at addressing these risk factors might be able to prevent cognitive decline in elderly people who are at risk of dementia.”

Lancet, http://dx.doi.org/10.1016/S0140-6736(15)60461-5.

The happy secret to better work

Can positivity make you more productive?

We’ve all heard (and intrinsically know!) that positivity is generally a good force in our lives but can it make us more successful and more productive?

Psychologist Shawn Achor certainly thinks so.  In this entertaining video he argues that happiness actually inspires productivity.

 

Internet use among the elderly ‘good for health’ – article from the Irish Medical Times

VariousOlder people who are active internet users and who regularly indulge in culture may be better able to retain their health literacy, and therefore maintain good health, suggests research published online in the Journal of Epidemiology and Community Health.

The Institute of Medicine defines health literacy as the degree to which a person is able to obtain, understand, and process basic health information so they can make appropriate decisions about their health.

Low levels of health literacy are associated with poorer self-care, higher use of emergency care services, low levels of preventative care, and an overall increased risk of death.

The most important factor governing a decline in health literacy in later years is thought to be dwindling cognitive abilities as a result of ageing, which gradually dulls the brain functions involved in active learning and vocabulary.

The researchers wanted to find out if regular internet use and engaging in civic, leisure, and cultural activities might help to maintain health literacy skills, irrespective of age-related cognitive decline. They therefore assessed the health literacy skills of almost 4,500 adults aged 52 and older, all of whom were taking part in the English Longitudinal Study of Ageing (ELSA) between 2004 and 2011.

At the start of the study, around three out of four people (73 per cent) had adequate health literacy. After six years, scores fell by one or more points in around a fifth (19 per cent) of people, regardless of their initial score, while a similar proportion improved by one or more points.

There was a link between age and declining health literacy, and being non-white, having relatively low wealth, few educational qualifications, and difficulties carrying out routine activities of daily living.

Poorer memory and executive function scores at the start of the study were also linked to greater decline over the subsequent six years.

Around 40 per cent said they never used the internet or email, while one-in-three (32 per cent) said they did so regularly. Similar proportions said they engaged in civic (35 per cent) and/or leisure (31 per cent) activities over the six-year period.

Almost four out of 10 (39 per cent) said they had regularly engaged in cultural activities, such as going to the cinema, theatre, galleries, concerts or the opera, during this time.

Across all time points, internet use and engagement in civic, leisure, or cultural activities were lower among those whose health literacy declined.

J Epidemiol Community Health 2014;0:1–6. doi:10.1136/jech-2014-204733.

Healthy Brain Month

Multiple recent developments have inspired us at Dunphy Medical to focus on healthy brains this month, here are a few of them.

  • Trinity College in association with the EU recently launched Hello Brain, a website and free app that promotes mental agility, brain health and understanding of this fascinating organ, follow a link to their site here http://www.hellobrain.eu/en/
  • This October Bank Holiday weekend (25th-27th October), Muintir na Tíre is organising a National Active Community Weekend in conjunction with Console to promote mental health.
  • TedTalks, (a favourite reference on this site as frequent visitors know) have a great playlist this week called How Does My Brain Work which features 9 videos on separate aspects of brain function.

Here’s one of those TedTalks by Daniel Wolpert  called The Real Reason For Brains, I hope you find it as interesting as I did.  It also greatly supports and explains the rationale of a physical therapy which I use in my practice (Neural Organisation Technique – N.O.T.) which I have found of great benefit in head, spinal and other physical injuries, and also unexpectedly in dyslexia and learning disorders over the past 30 years. Further information on N.O.T. can be found on this blog by clicking on Neural Organisation Technique under Categories, a section that shows on the left side of our home page.

 

 

We’ve added more videos from this TedTalks series on our Facebook pages https://www.facebook.com/dunphymedical and http://www.facebook.com/pages/Dr-Sean-Dunphy/173021722744006?ref=hl and there is always endless content on http://www.ted.com/ too.

In 2006 I had the unique experience (for a short time) of using umbilical cord stem cells in a range of chronic diseases. Because of this experience I was invited as a guest speaker to the European Anti-ageing Conference in Athens, Greece in 2007 and to the World Anti-ageing Conference at the Palais de Congres in Paris the following year.

A fellow speaker from Oxford presented some fascinating new information on how spectacularly adaptive and regenerative the brain is, this quality is called plasticity. Brain plasticity was believed to be impossible as recently as approximately 10 years ago, so all medical textbooks more than 10 years old are 100% wrong in relation to brain plasticity and are best thrown on your next bonfire!!

We can thank the humble canary bird for our first scientific breakthrough in this regard, it generates 500,000 new neural (brain) cells learning a new song every spring – neural stem cells are a key player in learning and memory.

A study of London taxi-drivers who memorised and learned the ‘knowledge’ ie a map of London’s many streets like an internal GPS, showed a  14% growth of the hippocampus (the area of the brain responsible for memory) after just 9 months.

Another study found that when rats learned to navigate a new maze, after only 5 trials they developed more than 20,000 new brain cells. The control group of rats that just ran around a ring for the same time showed no increase in brain cells.

Here’s a video neatly summarising neuroplasticity courtesy of http://www.HelloBrain.eu

 

 

 

Here’s a video from http://www.HelloBrain.eu summarising the best ways to keep your brain healthy